Pre-frailty factors in community-dwelling 40-75 year olds: opportunities for successful ageing.

摘要: There is little known about pre-frailty attributes or when changes which contribute to frailty might be detectable and amenable change. This study explores in independent community-dwelling adults aged 40–75 years. Participants were recruited through local council networks, a national bank one university Adelaide, Australia. Fried phenotype scores calculated from measures of unintentional weight loss, exhaustion, low physical activity levels, poor hand grip strength slow walking speed. identified as not frail (no phenotypes), pre-frail (one two phenotypes) (three more phenotypes). Factor analysis was applied binary forms 25 published Differences tested mean factor between the three phenotypes ROC curves estimated predictive capacity factors. Of 656 participants (67% female; age 59.9 years, SD 10.6) 59.2% classified frail, 39.0% 1.8% frail. no gender differences. Seven factors identified, incorporating all measures. Factors 1 7 significantly predicted progression not-frail (Factor AUC 0.64 (95%CI 0.60–0.68, combined dynamic trunk stability lower limb functional strength, balance, foot sensation, hearing, lean muscle mass BMI; 0.55 0.52–0.59) comprising continence nutrition. 3 4 0.65 (95% CI 0.59–0.70)), combining living alone, sleep quality, depression anxiety, lung function; 0.60 0.54–0.66) perceived exertion on exercise, falls history. research states people their 40s 50s. Pre-frailty body systems performance can detected by range mutable measures, interventions prevent could commenced fourth decade life.