RNA Ribozyme which cleaves substrate RNA without formation of a convalent bond
作者： Arthur J. Zaug , Thomas R. Cech , Michael D. Been
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摘要: RNA enzymes or ribozymes can act as endoribonucleases, catalyzing the cleavage of molecules with a sequence specificity greater than that known ribonucleases and approaching DNA restriction endonucleases, thus serving specific endoribonucleases. An example is shortened form self-splicing ribosomal intervening Tetrahymena (L-19 IVS RNA). Site-specific mutagenesis enzyme active site L-19 alters substrate in predictable manner, allowing set sequence-specific endoribonucleases to be synthesized. Varying conditions allow ribozyme polymerase (nucleotidyltransferase), dephosphorylase (acid phosphatase phosphotransferase) endoribonuclease.
lens.org 参考文章(47)
Sidney Altman, Ribonuclease P: An Enzyme with a Catalytic RNA Subunit Advances in Enzymology - and Related Areas of Molecular Biology. ,vol. 62, pp. 1- 36 ,(1989) , 10.1002/9780470123089.CH1
Harvey F. Lodish, Molecular Cell Biology ,(1986)
R.B. Waring, C. Scazzocchio, T.A. Brown, R.W. Davies, S. Brenner, Close relationship between certain nuclear and mitochondrial introns. Implications for the mechanism of RNA splicing. Journal of Molecular Biology. ,vol. 167, pp. 595- 605 ,(1983) , 10.1016/S0022-2836(83)80100-4
Brenda L. Bass, Thomas R. Cech, Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA Nature. ,vol. 308, pp. 820- 826 ,(1984) , 10.1038/308820A0
G. A. PRODY, J. T. BAKOS, J. M. BUZAYAN, I. R. SCHNEIDER, G. BRUENING, Autolytic Processing of Dimeric Plant Virus Satellite RNA Science. ,vol. 231, pp. 1577- 1580 ,(1986) , 10.1126/SCIENCE.231.4745.1577
Gerda van der Horst, Henk F. Tabak, Self-splicing of yeast mitochondrial ribosomal and messenger RNA precursors. Cell. ,vol. 40, pp. 759- 766 ,(1985) , 10.1016/0092-8674(85)90335-6
R. van der Veen, A.C. Arnberg, G. van der Horst, L. Bonen, H.F. Tabak, L.A. Grivell, Excised group II introns in yeast mitochondria are lariats and can be formed by self-splicing in vitro. Cell. ,vol. 44, pp. 225- 234 ,(1986) , 10.1016/0092-8674(86)90756-7
A Jacquier, M Rosbash, Efficient trans-splicing of a yeast mitochondrial RNA group II intron implicates a strong 5' exon-intron interaction. Science. ,vol. 234, pp. 1099- 1104 ,(1986) , 10.1126/SCIENCE.2430332
Kelly Kruger, Paula J. Grabowski, Arthur J. Zaug, Julie Sands, Daniel E. Gottschling, Thomas R. Cech, Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena Cell. ,vol. 31, pp. 147- 157 ,(1982) , 10.1016/0092-8674(82)90414-7
Richard B. Waring, Paul Towner, Stephen J. Minter, R. Wayne Davies, Splice-site selection by a self-splicing RNA of tetrahymena Nature. ,vol. 321, pp. 133- 139 ,(1986) , 10.1038/321133A0