Presence of erg gene rearrangements and protein over-expression in low grade pin (lg-pin) in prostate biopsies

作者: Gary Pestano , Connie Cortez , Karl Garsha , Ryan Dittamore , Alexandra Dea Nagy

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摘要: The present disclosure relates to methods for the early detection of ERG over-expression, gene rearrangements, and diagnosis and/or prognosis prostate cancer using a combined IHC-FISH assay. An exemplary method comprises: providing sample from subject; detecting presence or absence in fusion having 5' portion transcriptional regulatory region an androgen regulated 3' by chromosomal rearrangements genomic DNA nucleic acid hybridization technique, over-expression protein immunohistochemistry assay wherein both over expression is indicative low-grade PIN subject that predictive said has previously been determined as negative cancer.

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