The expanding world of tRNA modifications and their disease relevance.
作者： Tsutomu Suzuki
DOI: 10.1038/S41580-021-00342-0
关键词:
摘要: Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post-transcriptionally. A wide variety of tRNA modifications found the anticodon, which crucial for precise recognition and reading frame maintenance, thereby ensuring accurate efficient In addition, tRNA-body regions also frequently thus stabilized cell. Over past two decades, 16 novel were discovered various organisms, chemical space modification continues to expand. Recent studies have revealed can be dynamically altered response levels cellular metabolites environmental stresses. Importantly, we now understand deficiencies pathological consequences, termed ‘RNA modopathies’. Dysregulation involved mitochondrial diseases, neurological disorders cancer. RNAs (tRNAs) heavily post-transcriptionally, number types continually expanding. show stresses, cause
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Nobuyoshi Fukuhara, Susumu Tokiguchi, Kenichi Shirakawa, Tadao Tsubaki, Myoclonus epilepsy associated with ragged-red fibres (mitochondrial abnormalities): Disease entity or a syndrome?: Light- and electron-microscopic studies of two cases and review of literature☆ Journal of the Neurological Sciences. ,vol. 47, pp. 117- 133 ,(1980) , 10.1016/0022-510X(80)90031-3
Martin Benej, Silvia Pastorekova, Jaromir Pastorek, Carbonic Anhydrase IX: Regulation and Role in Cancer Subcellular Biochemistry. ,vol. 75, pp. 199- 219 ,(2014) , 10.1007/978-94-007-7359-2_11
Stephen W. Schaffer, Chian Ju Jong, Danielle Warner, Takashi Ito, Junichi Azuma, Taurine deficiency and MELAS are closely related syndromes. Advances in Experimental Medicine and Biology. ,vol. 776, pp. 153- 165 ,(2013) , 10.1007/978-1-4614-6093-0_16
Yuriko Sakaguchi, Kenjyo Miyauchi, Byeong-il Kang, Tsutomu Suzuki, Nucleoside Analysis by Hydrophilic Interaction Liquid Chromatography Coupled with Mass Spectrometry. Methods in Enzymology. ,vol. 560, pp. 19- 28 ,(2015) , 10.1016/BS.MIE.2015.03.015
Susumu Nishimura, Structure, biosynthesis, and function of queuosine in transfer RNA. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 28, pp. 49- 73 ,(1983) , 10.1016/S0079-6603(08)60082-3
John Karijolich, Chengqi Yi, Yi-Tao Yu, Transcriptome-wide dynamics of RNA pseudouridylation. Nature Reviews Molecular Cell Biology. ,vol. 16, pp. 581- 585 ,(2015) , 10.1038/NRM4040
Jesper S. Krog, Yaiza Español, Anders M. B. Giessing, Agnieszka Dziergowska, Andrzej Malkiewicz, Lluís Ribas de Pouplana, Finn Kirpekar, 3-(3-amino-3-carboxypropyl)-5,6-dihydrouridine is one of two novel post-transcriptional modifications in tRNALys(UUU) from Trypanosoma brucei. FEBS Journal. ,vol. 278, pp. 4782- 4796 ,(2011) , 10.1111/J.1742-4658.2011.08379.X
Tsutomu Suzuki, Yoshiho Ikeuchi, Akiko Noma, Takeo Suzuki, Yuriko Sakaguchi, Mass spectrometric identification and characterization of RNA-modifying enzymes. Methods in Enzymology. ,vol. 425, pp. 211- 229 ,(2007) , 10.1016/S0076-6879(07)25009-8
Effect of diet on the queuosine family of tRNAs of germ-free mice. Journal of Biological Chemistry. ,vol. 255, pp. 6832- 6835 ,(1980) , 10.1016/S0021-9258(18)43648-4
Shana O. Kelley, Paul Schimmel, Sergey V. Steinberg, Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility Nature Structural & Molecular Biology. ,vol. 7, pp. 862- 865 ,(2000) , 10.1038/79612