Central Nervous System Inflammation and Neurological Disease in Transgenic Mice Expressing the CC Chemokine CCL21 in Oligodendrocytes

摘要: To study the biological role of chemokine ligands CCL19 and CCL21, we generated transgenic mice expressing either gene in oligodendrocytes CNS. While all CNS developed normally, most (18 26) CCL21 founder a neurological disease that was characterized by loss landing reflex, tremor, ataxia. These signs were observed as early postnatal day 9 associated with weight death during first 4 wk life. Microscopic examination brain spinal cord revealed scattered leukocytic infiltrates consisted primarily neutrophils eosinophils. Additional findings included hypomyelination, spongiform myelinopathy evidence myelin breakdown, reactive gliosis. Thus, ectopic expression CC but not CCL19, induced significant inflammatory response However, neither sufficient to recruit lymphocytes into observations are striking contrast reported activities these molecules vitro may indicate specific requirements for their activity vivo.