Acute lung injury in endotoxemic pigs: role of leukotriene B4.

摘要: The role of leukotriene B4 (LTB4) in the pathogenesis acute lung injury was examined endotoxemic pigs. In a preliminary study, activity and specificity an LTB4-receptor antagonist, LY-306669, were evaluated. vitro, LY-306669 completely blocked functional upregulation phagocyte opsonin receptors induced by LTB4 but had much smaller effect on receptor platelet-activating factor. pigs treatment with prevented leukopenia injection authentic no hematologic or hemodynamic effects PAF U-48816, thromboxane-A2 mimetic. second received intravenous priming dose lipopolysaccharide (LPS) at time (t) = -18 h randomized to receive 1) further (n 5), 2) LPS (250 micrograms/kg over 1 beginning t 0 h) (10 mg/kg bolus 3 mg.kg-1.h-1 infusion -15 min) 7), 3) vehicle 6). Treatment significantly ameliorated LPS-induced hypoxemia, pulmonary edema, alveolitis. These data suggest that is important mediator dysfunction transendothelial migration neutrophils injury.