The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2.
作者： Juan Zhang , Zhaoqing Zheng , Man Wu , Li Zhang , Jing Wang
DOI: 10.1038/S41419-019-1789-5
关键词:
摘要: Tumor metastasis is the predominant cause of lethality in cancer. We found that Neobractatin (NBT), a natural compound isolated from Garcinia bracteata, could efficiently inhibit breast and lung cancer cells metastasis. However, mechanisms NBT inhibiting remain unclear. Based on RNA-sequencing result transcriptome analysis, Muscleblind-like 2 (MBNL2) was to be significantly upregulated treated with NBT. The Cancer Genome Atlas (TCGA) database analysis indicated expression MBNL2 carcinoma tumor tissues lower compared normal tissues. thus conducted investigate antimetastatic role MBNL2. overexpression mimicked effect cell motility metastasis, addition enhanced inhibition knockdown furthermore partially eliminated inhibitory Mechanistically, we demonstrated NBT- MBNL2-mediated antimetastasis regulation correlated pAKT/epithelial-mesenchymal transition (EMT) pathway. Subsequent vivo study showed same MDA-MB-231 xenografts mouse model. This suggest possesses significant antitumor activity partly mediated through enhancement via pAKT/EMT signaling
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