Scalable synthesis and derivation of functional polyesters bearing ene and epoxide side chains

摘要: Functional polyester chemistry is well suited to improve delivery of biomacromolecular drugs because it enables tuning degradation profiles and inclusion key functional groups (e.g. cationic charges for nucleic acid binding). However, current approaches introduce functionality suffer from inadequate scalability modularity. We have developed a scalable library polyesters based on the polymerization trimethylolpropane allyl ether (TPAE) with diacid chlorides (poly(TPAE-co-AC)s). The reactive side chains can be easily modified various thiols alkyl-, amino-, PEG-) amines generate diverse set materials, thereby potential opportunities in drug delivery. occurs readily under mild conditions at room temperature Mw poly(TPAE-co-suberoyl chloride) exceeding 42000 g mol−1. In addition, poly(TPAE-co-adipoyl was polymerized 100+ gram scale 71% final isolated yield. Due structural similarity established non-functional such as PLGA, these new materials may find broad application gene delivery, tissue engineering, other nanotechnology applications.