Indicators of Postoperative Pain in Syrian Hamsters (Mesocricetus auratus).

摘要: Despite the use of Syrian hamsters (Mesocricetus auratus) in research, little is known about evaluation pain this species. This study investigated whether frequency certain behaviors, a grimace scale, treat-take-test proxy indicator, body weight, water consumption, and coat appearance could be monitored as signs postoperative research setting. Animals underwent no manipulation, anesthesia only or laparotomy under anesthesia. An ethogram was constructed used to determine frequencies pain, active passive behaviors by in-person remote videorecording observation methods. The Hamster Grimace Scale (SHGS) developed for facial expressions before after surgery. assessed surgery would affect animals' motivation take high-value food item from handler. hypothesis that behavior frequency, score, change baseline group but not no-intervention anesthesia-only groups. At several time points, were higher than during SHGS score increased scores 3 9 animals studied highly specific poorly sensitive tools identify with pain. Behaviors category exhibited chiefly, solely, laparotomy. Also, many did show category. Treat-take-test scores, any Overall, methods we tested identifying experiencing effective. More needed regarding clinically relevant strategies assess hamsters.