Association between Dietary Patterns and Atopic Dermatitis in Relation to GSTM1 and GSTT1 Polymorphisms in Young Children

摘要: Previous research suggests the association of glutathione S-transferase (GST) gene polymorphisms or diet, but no interactions between these factors in atopic dermatitis (AD). We conducted a community-based case-control study including 194 AD and 244 matched non-AD preschoolers. Glutathione M1 (GSTM1) T1 (GSTT1) present/null genotypes were evaluated uisng multiplex PCR method. measured dietary intakes by validated food frequency questionnaire constructed three patterns such as "traditional healthy", "animal foods", "sweets" diets. In stratified analyses GST genotypes, healthy" diet reduced showed only GSTM1-present group (odd ratio (OR) 0.31, 95% confidence interval (CI) 0.13-0.75). A similar pattern existed combined GSTM1/T1 genotype that indicated inverse double GSTM1/T1-present (OR 0.24, CI 0.06-0.93). Results from multiplicative test on was significant borderline 0.71, 0.54-0.92 vs. GSTM1-null group) present 0.63, 0.39-1.03 null group). These findings demonstrate type GSTM1 may increase susceptibility to potential effect AD.