Radical approach to diabetic nephropathy

摘要: There is increasing evidence that reactive oxygen species (ROS) play a major role in the development of diabetic complications. Oxidative stress increased diabetes and chronic kidney disease (CKD). High glucose upregulates transforming growth factor- β 1 (TGF- 1) angiotensin II (Ang II) renal cells high glucose, TGF- 1, Ang all generate signal through ROS. ROS mediate glucose-induced activation protein kinase C nuclear κ B cells. Intensive glycemic control inhibition delay onset progression nephropathy, part, antioxidant activity. Conventional catalytic antioxidants were shown to prevent or nephropathy. Transketolase activators poly (ADP-ribose) polymerase inhibitors block biochemical pathways hyperglycemic damage. Combination strategies overproduction ROS, increase removal preformed ROS-induced leading cellular damage may prove effective preventing CKD diabetes.