Efficacy of micronised vaginal progesterone versus oral dydrogestrone in the treatment of irregular dysfunctional uterine bleeding: A pilot randomised controlled trial
作者： Savas KARAKUS , Gurkan KIRAN , Harun CIRALIK
DOI: 10.1111/J.1479-828X.2009.01093.X
关键词:
摘要: Background: The vaginal route is more effective than the other drug delivery routes for some specific indications. Aim: To compare efficacy of a progesterone preparation with that oral dydrogesterone. Methods: A total 69 women irregular dysfunctional uterine bleeding were randomly assigned into one two groups: dydrogesterone group (n = 35) and (n = 34). At end three-month treatment period, re-evaluated. endometrial histology findings menstrual cycle characteristics used as primary outcome measures. Pearson chi-square Fisher’s exact test data analysis. Results: Findings from 54 eligible evaluated. There was no statistically significant difference in both recordings results between groups. Conclusions: Vaginal micronised could be an alternative to preparations bleeding. This needs further evaluated adequately controlled randomised trials against treatments.
sci-hub.se 参考文章(32)
Rachel A. Miles, Richard J. Paulson, Rogerio A. Lobo, Michael F. Press, Laila Dahmoush, Mark V. Sauer, Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study Fertility and Sterility. ,vol. 62, pp. 485- 490 ,(1994) , 10.1016/S0015-0282(16)56935-0
Lorene M. Kimzey, Julie Gumowski, George R. Merriam, George J. Grimes, Lawrence M. Nelson, Absorption of micronized progesterone from a nonliquefying vaginal cream**Presented at the 38th Annual Meeting of the Society for Gynecologic Investigation, San Antonio, Texas, March 20 to 23, 1991. Fertility and Sterility. ,vol. 56, pp. 995- 996 ,(1991) , 10.1016/S0015-0282(16)54680-9
Peter HM Van de Weijer, Ronald Barentsen, Michiel De Vries, Peter Kenemans, Relationship of estradiol levels to breakthrough bleeding during continuous combined hormone replacement therapy. Obstetrics & Gynecology. ,vol. 93, pp. 551- 557 ,(1999) , 10.1016/S0029-7844(98)00525-0
D de Ziegler, Progesterone and progestins: applications in gynecology. Steroids. ,vol. 65, pp. 671- 679 ,(2000) , 10.1016/S0039-128X(00)00123-9
Samuel J Chantilis, Khaled M Zeitoun, Snehal I Patel, D.Alan Johns, Valerie A Madziar, Donald D McIntire, Use of Crinone∗ vaginal progesterone gel for luteal support in in vitro fertilization cycles∗∗Crinone 8% (90 mg), Columbia Research Laboratories, Miami, Florida. Fertility and Sterility. ,vol. 72, pp. 823- 829 ,(1999) , 10.1016/S0015-0282(99)00362-3
Anthony M Propst, Joseph A Hill, Elizabeth S Ginsburg, Shelley Hurwitz, Joseph Politch, Elena H Yanushpolsky, A randomized study comparing Crinone 8%∗ and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles1 ∗Crinone 8%, Serono Laboratories, Inc., Randolph, Massachusetts. 1The opinions and conclusions in this paper are those of the authors and are not intended to represent the official position of the U.S. Department of Defense, the United States Air Force, or any other government agency. Fertility and Sterility. ,vol. 76, pp. 1144- 1149 ,(2001) , 10.1016/S0015-0282(01)02872-2
Mark A Damario, Vasilios T Goudas, Donna R Session, Diane G Hammitt, Daniel A Dumesic, Crinone 8%∗∗Crinone 8%, Wyeth-Ayerst Laboratories, Inc., Philadelphia, Pennsylvania. vaginal progesterone gel results in lower embryonic implantation efficiency after in vitro fertilization-embryo transfer Fertility and Sterility. ,vol. 72, pp. 830- 836 ,(1999) , 10.1016/S0015-0282(99)00364-7
Ketan Jobanputra, James P Toner, Rita Denoncourt, William E Gibbons, Crinone 8% (90 mg)∗∗Crinone 8%, Serono Laboratories, Inc., Norwell, Massachusetts. given once daily for progesterone replacement therapy in donor egg cycles22Sponsored by Columbia Research Laboratories, Inc., Rockville Centre, New York. Fertility and Sterility. ,vol. 72, pp. 980- 984 ,(1999) , 10.1016/S0015-0282(99)00390-8
C. Banz, A. Katalinic, S. Al-Hasani, A.S. Seelig, J.M. Weiss, K. Diedrich, M. Ludwig, Preparation of cycles for cryopreservation transfers using estradiol patches and Crinone® 8% vaginal gel is effective and does not need any monitoring European Journal of Obstetrics & Gynecology and Reproductive Biology. ,vol. 103, pp. 43- 47 ,(2002) , 10.1016/S0301-2115(02)00004-0
Selmo Geber, Ana Carolina Ferreira Moreira, Sálua Oliveira Calil de Paula, Marcos Sampaio, Comparison between two forms of vaginally administered progesterone for luteal phase support in assisted reproduction cycles Reproductive Biomedicine Online. ,vol. 14, pp. 155- 158 ,(2007) , 10.1016/S1472-6483(10)60782-1