Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy.

摘要: To define altered metabolites in the brain of patients with probable Alzheimer disease (AD) two regions, localized vivo hydrogen-1 magnetic resonance (MR) spectroscopy was performed a short echo time (30 msec) 11 elderly and 10 healthy age-matched subjects. The had mild to moderate dementia, assessed standard neuropsychological tests. Two abnormalities patients' cerebral cortex were defined: When compared subjects, showed 22% increase (P = .005) (approximately equal 1.5 mmol/kg) myo-inositol (MI) an 11% decrease residues N-acetyl (NA), putative neuronal marker. elevation MI AD suggests that inositol polyphosphate messenger pathway occur early natural history AD. combination high low NA at examination H-1 MR shows promise as diagnostic test for