High dose rate brachytherapy as monotherapy for localised prostate cancer.
作者： Iosif Strouthos , Nikolaos Tselis , Georgios Chatzikonstantinou , Saeed Butt , Dimos Baltas
DOI: 10.1016/J.RADONC.2017.09.038
关键词:
摘要: Abstract Background and purpose To evaluate the oncological outcome of a three-implant high dose rate (HDR) brachytherapy (BRT) protocol as monotherapy for clinically localised prostate cancer. Material methods Between February 2008 December 2012, 450 consecutive patients with cancer were treated HDR monotherapy. The cohort comprised 198 low-, 135 intermediate- 117 risk being three single-fraction implants 11.5 Gy delivered to an intraoperative real-time, transrectal ultrasound defined planning treatment volume up total physical 34.5 Gy interfractional interval 21 days. Fifty-eight (12.8%) received ADT, 32 whom high- 26 intermediate-risk. Biochemical failure was according Phoenix Consensus Criteria genitourinary/gastrointestinal toxicity evaluated using Common Toxicity Adverse Events version 3.0. Results median follow-up time 56.3 months. 60-month overall survival, biochemical control metastasis-free-survival rates 96.2%, 95.0% 99.0%, respectively. scored per event late Grade 2 3 genitourinary adverse events 14.2% 0.8%, Late gastrointestinal amounted 0.4% no instances or greater be reported. Conclusions Our results confirm BRT safe effective monotherapeutic modality
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