Relationship of the three dimensional structure of carboxypeptidase A to catalysis

作者: William N. Lipscomb

DOI: 10.1016/S0040-4020(01)97306-5

关键词:

摘要: Abstract A brief discussion is presented of activity, conformational changes, possible mechanisms, intermediates, and pH effects in the peptidase activity hydrolytic enzyme, carboxypeptidase A.

参考文章(29)
Emil L. Smith, Action of carboxypeptidase on peptide derivatives of L-tryptophan. Journal of Biological Chemistry. ,vol. 175, pp. 39- 47 ,(1948) , 10.1016/S0021-9258(18)57231-8
Florante A. Quiocho, William N. Lipscomb, Carboxypeptidase A: a protein and an enzyme. Advances in Protein Chemistry. ,vol. 25, pp. 1- 78 ,(1971) , 10.1016/S0065-3233(08)60278-8
Mark Arnold Stahmann, Joseph S. Fruton, Max Bergmann, The specificity of carboxypeptidase. Journal of Biological Chemistry. ,vol. 164, pp. 753- 760 ,(1940) , 10.1016/S0021-9258(17)41276-2
B. L. Kaiser, E. T. Kaiser, EFFECT OF D2O ON THE CARBOXYPEPTIDASE-CATALYZED HYDROLYSIS OF O-(trans-CINNAMOYL)-L-β-PHENYLLACTATE AND N-(N-BENZOYLGLYCYL)-L-PHENYLALANINE Proceedings of the National Academy of Sciences of the United States of America. ,vol. 64, pp. 36- 41 ,(1969) , 10.1073/PNAS.64.1.36
J. T. Johansen, B. L. Vallee, Conformations of Arsanilazotyrosine-248 Carboxypeptidase Aα,β,γ. Comparison of Crystals and Solution Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 2006- 2010 ,(1973) , 10.1073/PNAS.70.7.2006
W. N. Lipscomb, J. A. Hartsuck, F. A. Quiocho, G. N. Reeke, The structure of carboxypeptidase A. IX. The x-ray diffraction results in the light of the chemical sequence. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 64, pp. 28- 35 ,(1969) , 10.1073/PNAS.64.1.28
F. A. Quiocho, C. H. Mcmurray, W. N. Lipscomb, Similarities between the conformation of arsanilazotyrosine 248 of carboxypeptidase A in the crystalline state and in solution. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 69, pp. 2850- 2854 ,(1972) , 10.1073/PNAS.69.10.2850
Nurith Abramowitz, Israel Schechter, Arieh Berger, On the size of the active site in proteases II. Carboxypeptidase-A Biochemical and Biophysical Research Communications. ,vol. 29, pp. 862- 867 ,(1967) , 10.1016/0006-291X(67)90299-9
D. E. Koshland, Application of a Theory of Enzyme Specificity to Protein Synthesis Proceedings of the National Academy of Sciences. ,vol. 44, pp. 98- 104 ,(1958) , 10.1073/PNAS.44.2.98