Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells

摘要: In this study, we show the selective and efficient anti-cancer effects of plasma (at a low dose) when cell metabolic modifiers are also included. 2-deoxy-D-glucose (2-DG), glycolytic inhibitor, was used with effective doses non-thermal plasma, synergistically attenuating viability inducing caspase-dependent independent death. The combination treatment decreased intracellular ATP lactate production in various types blood cancer cells vitro. Taken together, our findings suggest that 2-DG enhances efficacy selectivity induces synergistic inhibition growth by targeting glycolysis apoptosis. Specifically, strategy demonstrated an enhanced inhibitory effect presence modifier against cells, not non-malignant cells. This is first study to report advantage combining eradicate Finally, conclude may be as