The inactivation of papain by high LET radiations.
作者： R.H. Bisby , R.B. Cundall , H.E. Sims , W.G. Burns
DOI: 10.1080/09553008414551381
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摘要: SummaryThe effect of varying LET over a wide range (0·2–1570 eV/nm) on the radiation-induced inactivation enzyme papain in dilute aqueous solution has been investigated. Measurements total, reparable and non-reparable G values oxygen, nitrous oxide argon saturated solutions have allowed contributions to from radicals hydrogen peroxide be evaluated. At high results demonstrate an increasing component due reaction superoxide radical, formed oxygen produced track as primary radiolysis product. This was not observed our previous study with ribonuclease insensitivity by peroxide. The obtained clearly maximum G(H2O2) at ∼140 eV/nm. Generation O2 within product now appears confirmed important mechanism leading reduction enhanceme...
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