The triptan formulations : how to match patients and products.

摘要: The 5-HT1b/1d receptor agonists (the ‘triptans’) are migraine-specific agents that have revolutionised the treatment of migraine. They usually drugs choice to treat a migraine attack in progress. Different triptans available various strengths and formulations, including oral tablets, orally disintegrating nasal sprays subcutaneous injections. In Europe, sumatriptan is also as suppository. Specific differences among exist, evidenced by different pharmacological profiles half-life, time peak plasma concentrations, area under concentration-time curve, metabolism drug-drug interaction profiles. How or whether these translate clinical efficacy tolerability advantages for one agent over another not well differentiated. However, delivery systems may play an important role onset action. Given distinctions subtle, identification most appropriate triptan individual patient requires consideration specific characteristics knowledge preference, accurate history previous acute-care medications features drug being considered. selection acute antimigraine depends upon stratification patient’s intensity, level associated symptoms such nausea vomiting, symptoms, comorbid diseases concomitant treatments might cause interactions. Individual response seems be idiosyncratic possibly genetically determined. Therefore, set questions can used determine currently optimally effective, dose needs increased should tried. clinician has his/her armamentarium ever-expanding variety triptans, multiple formulations dosages, which good safety Continued use will yield familiarity with it become possible interested physician match optimise therapeutic benefit. Use methods outlined this review choosing probably more likely lead relief than making educated guess appropriate.