Inhibition of human immunodeficiency virus type-1 through autophagy.
作者： Grant R Campbell , Stephen A Spector
DOI: 10.1016/J.MIB.2013.05.006
关键词:
摘要: As an obligatory intracellular pathogen, human immunodeficiency virus type-1 (HIV) is dependent upon its ability to exploit host cell machinery for replication and dissemination, circumvent cellular processes that prevent growth. One such process autophagy, a component of the defense against HIV with roles in innate immune signaling, adaptive immunity degradation HIV. During permissive infection, down-modulates promoting own replication. Inducers autophagy can overcome this suppression inhibit This review summarizes recent advances understanding antiviral replicative during infection. Dissecting molecular mechanisms by which utilizes may lead identification novel drug candidates treat potentially eradicate
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