Persistent Ventricle Partitioning in the Adult Zebrafish Heart

摘要: The vertebrate heart integrates cells from the early-differentiating first field (FHF) and later-differentiating second (SHF), both emerging lateral plate mesoderm. In mammals, this process forms basis for development of left right ventricle chambers subsequent chamber septation. single ventricle-forming zebrafish also FHF SHF lineages during embryogenesis, yet contributions these two myocardial to adult remain incompletely understood. Here, we characterize labeling descendants in developing ventricle. Expanding previous findings, late gastrulation-stage using drl-driven CreERT2 recombinase with a myocardium-specific, myl7-controlled, loxP reporter results predominant FHF-derived outer curvature side embryonic Raised adulthood, such lineage-labeled hearts retain broad areas cardiomyocytes region that is positioned at opposite atrium encompasses apex. Our data add increasing evidence persisting cell-based compartmentalization even absence any physical boundary.