Toxic effects of ochratoxin A and citrinin, alone and in combination, on chicken embryos.

摘要: The embryotoxic potential of ochratoxin A and citrinin was studied after administering, either subgerminally or intraamniotically, single mounting doses the mycotoxins to chicken embryos on days 2, 3, 4. beginning embryotoxicity dose range found be between 0.01 0.05 microgram for 1 10 micrograms citrinin. maximum response both occurred administration day 3. In addition significant growth retardation fetuses, exencephaly, microphthalmia, cleft beak, reduction deformities limbs, abdominal wall ventricular septal defects were encountered 8 incubation. When 4 constantly added administered in 0.03 0.5 microgram, a strictly additive effect seen. It may supposed that produced together with some strains Penicillium viridicatum Westling does not potentiate clear-cut action latter mycotoxin.