One-Year Clinical and Radiological Results of a Prospective, Investigator-Initiated Trial Examining a Novel, Purely Autologous 3-Dimensional Autologous Chondrocyte Transplantation Product in the Knee.

摘要: Background:The 3-dimensional autologous chondrocyte transplantation (ACT3D) comprises isolation of chondrocytes from cartilage biopsies, cultivation to spheroids, and into the defect.Objectives:To evaluate patients’ general health functionality assess defect repair after ACT3D with spheroids by MRI MOCART scoring.Methods:Thirty-seven patients isolated chondral lesions knee underwent through medial arthrotomy. Patient-administered scores were assessed at baseline (day before transplantation), 6 weeks, 3, 6, 12 months. scoring performed 3 months ACT3D.Results:Patients diagnosed full-thickness patellofemoral (n = 16), femoral condylar 18), or both types 3), International Cartilage Repair Society (ICRS) grade 4, sizes between 1.0 12.0 cm2. On average, 59.5 spheroids/cm2 in size transplanted. An overall statistically sign...