Cloning of SV40sv40 genomes from human brain tumors

作者: Peter Krieg , Gerd Scherer

DOI: 10.1016/0042-6822(84)90357-X

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摘要: From two human brain tumors SV40 genomes were isolated by recombinant DNA techniques. The genome cloned from a meningioma was shown to be indistinguishable wild-type SV40. In contrast, the astrocytoma proved nonviable deletion mutant with truncated early region removing most of large T-coding region. addition, this also carries tandem duplication an intact origin replication.

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