Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy.

摘要: Recent studies with very small numbers of patients showed that in some cases childhood acute lymphoblastic leukemia (ALL), preleukemic cells are detectable on Guthrie cards were used for newborn screening. We present here the largest series ALL (n=32) whom analyzed presence cells. Rearranged immunoglobulin heavy-chain genes as a marker leukemic clones. combined our set 17 previously published cases. Preleukemic detected 31 all 49 (63%). Positive screening not associated patient's age at diagnosis but almost always found hyperdiploidy (10/11; 91%; P=0.04). High birth weight is an established risk factor ALL. strongly low (P=0.01). In conclusion, majority B-precursor arise prior to birth. search causes we should concentrate prenatal factors well postnatal factors. Our results suggest autologous cord bloods could be poor choice source stem transplantation leukemia, which may contain Pending development suitable methods, potentially screenable disease.