STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
作者： Joseph P. Yuan , Weizhong Zeng , Guo N. Huang , Paul F. Worley , Shmuel Muallem
DOI: 10.1038/NCB1590
关键词:
摘要: Stromal interacting molecule 1 (STIM1) is a Ca2+ sensor that conveys the load of endoplasmic reticulum to store-operated channels (SOCs) at plasma membrane. Here, we report STIM1 binds TRPC1, TRPC4 and TRPC5 determines their function as SOCs. Inhibition inhibits activation by receptor stimulation, but not La3+, suggesting obligatory for TRPC agonists, essential channel function. Through distinct mechanism, also regulates TRPC3 TRPC6. does bind TRPC6, indirectly mediating heteromultimerization with TRPC1 TRPC6 TRPC4. TRPC7 regulated STIM1. We propose new definition SOCs, are require store depletion-mediated clustering By this definition, all channels, except TRPC7,
nature.com
elsevier.com
sci-hub.se 参考文章(44)
Michael J. Berridge, Martin D. Bootman, H. Llewelyn Roderick, Calcium signalling: dynamics, homeostasis and remodelling. Nature Reviews Molecular Cell Biology. ,vol. 4, pp. 517- 529 ,(2003) , 10.1038/NRM1155
Marc Freichel, Suk Hyo Suh, Alexander Pfeifer, Ulli Schweig, Claudia Trost, Petra Weißgerber, Martin Biel, Stephan Philipp, Doris Freise, Guy Droogmans, Franz Hofmann, Veit Flockerzi, Bernd Nilius, Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nature Cell Biology. ,vol. 3, pp. 121- 127 ,(2001) , 10.1038/35055019
P A Loessberg, H Zhao, S Muallem, Synchronized oscillation of Ca2+ entry and Ca2+ release in agonist-stimulated AR42J cells. Journal of Biological Chemistry. ,vol. 266, pp. 1363- 1366 ,(1991) , 10.1016/S0021-9258(18)52300-0
Barbara Wedel, Rebecca R. Boyles, James W. Putney, Gary S. Bird, Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells The Journal of Physiology. ,vol. 579, pp. 679- 689 ,(2007) , 10.1113/JPHYSIOL.2006.125641
Kirill Kiselyov, Xin Xu, Galina Mozhayeva, Tuan Kuo, Isaac Pessah, Gregory Mignery, Xi Zhu, Lutz Birnbaumer#, Shmuel Muallem, Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature. ,vol. 396, pp. 478- 482 ,(1998) , 10.1038/24890
G Boulay, Ca2+-calmodulin regulates receptor-operated Ca2+ entry activity of TRPC6 in HEK-293 cells Cell Calcium. ,vol. 32, pp. 201- 207 ,(2002) , 10.1016/S0143416002001550
Jen Liou, Man Lyang Kim, Won Do Heo, Joshua T. Jones, Jason W. Myers, James E. Ferrell, Tobias Meyer, STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx Current Biology. ,vol. 15, pp. 1235- 1241 ,(2005) , 10.1016/J.CUB.2005.05.055
Hwei Ling Ong, Kwong Tai Cheng, Xibao Liu, Bidhan C Bandyopadhyay, Biman C Paria, Jonathan Soboloff, Biswaranjan Pani, Yousang Gwack, Sonal Srikanth, Brij B Singh, Donald Gill, Indu S Ambudkar, None, Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx EVIDENCE FOR SIMILARITIES IN STORE-OPERATED AND CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL COMPONENTS Journal of Biological Chemistry. ,vol. 282, pp. 9105- 9116 ,(2007) , 10.1074/JBC.M608942200
Yoichiro Takahashi, Manabu Murakami, Hiroyuki Watanabe, Hitoshi Hasegawa, Takayoshi Ohba, Yoshiko Munehisa, Kiyoshi Nobori, Kyoichi Ono, Toshihiko Iijima, Hiroshi Ito, Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry Biochemical and Biophysical Research Communications. ,vol. 356, pp. 45- 52 ,(2007) , 10.1016/J.BBRC.2007.02.107
Silke Jung, Anja Mühle, Michael Schaefer, Rainer Strotmann, Günter Schultz, Tim D. Plant, Lanthanides Potentiate TRPC5 Currents by an Action at Extracellular Sites Close to the Pore Mouth Journal of Biological Chemistry. ,vol. 278, pp. 3562- 3571 ,(2003) , 10.1074/JBC.M211484200