Manipulation of the innate immune response by human papillomaviruses.
作者： Shiyuan Hong , Laimonis A. Laimins
DOI: 10.1016/J.VIRUSRES.2016.11.004
关键词:
摘要: The innate immune response constitutes the first line of defense against infections by pathogens. Successful pathogens such as human papillomaviruses (HPVs) have evolved mechanisms that target several points in these pathways including sensing viral genomes, blocking synthesis interferons and inhibiting action JAK/STAT transcription factors. Disruption inhibitory contributes to ability HPVs establish persistent infections, which is major etiological factor development anogenital cancers. Interestingly, also positively activate members STAT-5 are important for their differentiation-dependent life cycle. activation induces ATM ATR DNA damage play critical roles HPV genome amplification. Targeting pharmaceuticals can provide novel opportunities inhibit
sci-hub.se 参考文章(60)
J.M. Huibregtse, M. Scheffner, P.M. Howley, A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. The EMBO Journal. ,vol. 10, pp. 4129- 4135 ,(1991) , 10.1002/J.1460-2075.1991.TB04990.X
K. Münger, B.A. Werness, N. Dyson, W.C. Phelps, E. Harlow, P.M. Howley, Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. The EMBO Journal. ,vol. 8, pp. 4099- 4105 ,(1989) , 10.1002/J.1460-2075.1989.TB08594.X
Laura Pacini, Claudia Savini, Raffaella Ghittoni, Djamel Saidj, Jerome Lamartine, Uzma A. Hasan, Rosita Accardi, Massimo Tommasino, Downregulation of Toll-Like Receptor 9 Expression by Beta Human Papillomavirus 38 and Implications for Cell Cycle Control. Journal of Virology. ,vol. 89, pp. 11396- 11405 ,(2015) , 10.1128/JVI.02151-15
Dimitry Spitkovsky, Steffen P. Hehner, Thomas G. Hofmann, Andreas Möller, M. Lienhard Schmitz, The Human Papillomavirus Oncoprotein E7 Attenuates NF-κB Activation by Targeting the IκB Kinase Complex Journal of Biological Chemistry. ,vol. 277, pp. 25576- 25582 ,(2002) , 10.1074/JBC.M201884200
Zhongyi Fan, Hanzhi Cui, Xiaojie Xu, Zhi Lin, Xuelin Zhang, Lei Kang, Baiyu Han, Jing Meng, Zhifeng Yan, Xiang Yan, Shunchang Jiao, MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3. Oncotarget. ,vol. 6, pp. 25266- 25280 ,(2015) , 10.18632/ONCOTARGET.4457
Shiv Pillai, Abul K. Abbas, Andrew H. Lichtman, Cellular and Molecular Immunology ,(1994)
Irene Lo Cigno, Marco De Andrea, Cinzia Borgogna, Silvia Albertini, Manuela M. Landini, Alberto Peretti, Karen E. Johnson, Bala Chandran, Santo Landolfo, Marisa Gariglio, The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters Journal of Virology. ,vol. 89, pp. 7506- 7520 ,(2015) , 10.1128/JVI.00013-15
Jong-Sup Park, Eun-Joo Kim, Ho-Jeong Kwon, Eun-Seong Hwang, Sung-Eun Namkoong, Soo-Jong Um, Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis Journal of Biological Chemistry. ,vol. 275, pp. 6764- 6769 ,(2000) , 10.1074/JBC.275.10.6764
Yueh-Ming Loo, Michael Gale, Immune Signaling by RIG-I-like Receptors Immunity. ,vol. 34, pp. 680- 692 ,(2011) , 10.1016/J.IMMUNI.2011.05.003
Jason Bodily, Laimonis A. Laimins, Persistence of human papillomavirus infection: keys to malignant progression Trends in Microbiology. ,vol. 19, pp. 33- 39 ,(2011) , 10.1016/J.TIM.2010.10.002