A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge.
作者： Peter B. Gilbert , John R. Mascola , Ying Huang , Amarendra Pegu , Bhavesh Borate
DOI: 10.1016/J.CHOM.2019.08.014
关键词:
摘要: Summary Passively administered broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have been shown to protect non-human primates (NHPs) against chimeric simian-human immunodeficiency virus (SHIV) infection. With data from multiple primate SHIV challenge studies that used single bNAbs, we conducted a meta-analysis examine relationship between predicted serum 50% neutralization titer (ID50) and infection outcome. In logistic model adjusts for bNAb epitopes viruses, ID50 had highly significant effect on risk (p
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