The rates of G:C-->T:A and G:C-->C:G transversions at CpG dinucleotides in the human factor IX gene.

摘要: We have identified eight independent transversions at CpG in 290 consecutive families with hemophilia B. These account for 16.3% of all our sample, yet the expected frequency random factor IX gene is only 2.6% (P T:A and G:C-->C:G) possess similar mutation rates (24.8 x 10(-10) 20.6 10(-10), respectively), which are about fivefold greater than comparable non-CpG dinucleotides. The enhancement suggests that model by mutations occur may need to be reevaluated. relationship, if any, between deamination 5-methyl cytosine remains defined.