Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats.

摘要: Abstract Glucose uptake, lactate release, ketone body utilization, spatial distribution of glucose, lactate, and ATP concentrations as well tissue pH distributions were systematically investigated in s.c. and/or “tissue-isolated” human breast cancer xenografts T-cell-deficient rnu/rnu rats. Large variations all parameters detected within between tumors indicating a very nonuniform substrate turnover. was taken up by xenografts. consumption rates increased with increasing glucose availabilities, implying that the uptake is mainly determined efficiency nutritive tumor blood flow. The average 0.37 µmol/g/min medullary 0.26 squamous cell carcinomas breast. At wet weights below 5 g, cancers consumed more than (2 P i.e. , availability, not metabolic demand cells.