Neuroimaging and genetic correlates of cognitive dysfunction in multiple sclerosis.

摘要: Cognitive impairment occurs in 40-70% of patients with multiple sclerosis (MS). It is observed even at the early stage disease, including clinically isolated syndrome (CIS). dysfunction develops irrespectively physical disability. Affected domains include: information processing speed, visuospatial abilities, attention, verbal memory and executive functions. deficits have relevant implication because their impact on daily living, quality life increased risk conversion from CIS to MS. In recent years issue cognitive MS became an important research problem. The fundamental aim understand neurobiological substrates these mental symptoms. As we know neurodegenerative process associated pathology cerebral cortex damage normal appearing brain tissue are potentially involved development Better assessment changes possible through improvement magnetic resonance imaging techniques. Influence genetic profile course MS, dysfunction, still under evaluation. Despite using new neuroimaging methods, substrate has not been clearly defined so far. Understanding mechanisms underlying symptoms may extend our knowledge pathophysiology disease also contribute strategies objectives for treatment. This paper provides a summary results obtained application conventional modern techniques assess structural pathologies occurring as well factors association dysfunction.