bcl-2 and Other Genomic Alterations in the Prognosis of Large-Cell Lymphoma

摘要: Approximately half the patients with diffuse or follicular large-cell mixed large- and small-cell lymphoma enter a prolonged remission are cured after receiving combined-drug therapy. It has been unclear, however, why other do not respond. We evaluated 54 previously untreated 20 lymphoma, all of whom had component Stage II through IV disease, subsequently treated combined chemotherapy. Different recurrent genomic defects were associated differences in response to treatment. Among 12 duplication chromosome 3p complete clinical median follow-up 39 months (11 survived). In contrast, seven 2p partial no treatment survival six (all died). 5 +3 survived), 3 4 +2 died. Twenty-three B-cell non-immunoblastic who bcl-2 oncogene rearrangement poorer therapy (7 23 remission) than without (21 26 remission). conclude that mixed-cell is relatively good prognosis poor prognosis. Because such multiple also common most types cancer, they may have general prognostic importance.