Role of Lung Apolipoprotein A-I in Idiopathic Pulmonary Fibrosis
作者： Tae Hoon Kim , Yoo Hoon Lee , Kyung Hun Kim , Shin Hwa Lee , Ji Yeon Cha
DOI: 10.1164/RCCM.200905-0659OC
关键词:
摘要: Rationale: Idiopathic pulmonary fibrosis (IPF) is caused by alterations in expression of proteins involved multiple pathways, including matrix deposition, inflammation, injury, and repair.Objectives: To understand the pathogenic changes lung protein IPF to evaluate apolipoprotein (Apo) A-I as a candidate therapeutic molecule.Methods: Two-dimensional electrophoresis was adopted for differential display proteomics. Reverse-transcriptase polymerase chain reaction, Western blotting, immunohistochemical staining, ELISA were performed identification quantitative measurement Apo bronchoalveolar lavage fluids from subjects with experimental bleomycin-induced mice.Measurements Main Results: Sixteen spots showed differences relative intensity between (n = 14) healthy control 8). Nano liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed increase haptoglobulin decrease α1-antitrypsin, α1-antichymotrypsin...
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