Intranasal and intravenous administration of octa-arginine modified poly(lactic-co-glycolic acid) nanoparticles facilitates central nervous system delivery of loperamide.
作者： Aisling O'Donnell , Azeema Moollan , Samantha Baneham , Melike Ozgul , Ritesh M. Pabari
DOI: 10.1111/JPHP.12347
关键词:
摘要: Objectives The potential of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) surface modified with octa-arginine (R8) for central nervous system (CNS) delivery was investigated. Methods PLGA NPs containing coumarin-6 or loperamide were using R8 and characterised size, zeta potential, drug loading release. We examined the cellular uptake in Madin-Darby Canine Kidney (MDCK) cells CNS a mouse model following intranasal (i.n.) intravenous (i.v.) administration. Key findings NPs 300–350 nm diameter negative which neutralised on conjugation. Cellular R8-PLGA rapid compared PLGA correlated high antinociceptive effect mice by both i.n. i.v. routes. Little observed reflecting their slow in-vitro cell model. Conclusion This study demonstrates as carriers therapeutic agents to CNS.
sci-hub.se 参考文章(29)
Zebunnissa Ramtoola, Pierce Lyons, Kieran Keohane, Steve W. Kerrigan, Brian P. Kirby, John G. Kelly, Investigation of the interaction of biodegradable micro- and nanoparticulate drug delivery systems with platelets. Journal of Pharmacy and Pharmacology. ,vol. 63, pp. 26- 32 ,(2010) , 10.1111/J.2042-7158.2010.01174.X
William M. Pardridge, Blood-brain barrier delivery. Drug Discovery Today. ,vol. 12, pp. 54- 61 ,(2007) , 10.1016/J.DRUDIS.2006.10.013
J Vandervoort, A Ludwig, Biocompatible stabilizers in the preparation of PLGA nanoparticles: a factorial design study. International Journal of Pharmaceutics. ,vol. 238, pp. 77- 92 ,(2002) , 10.1016/S0378-5173(02)00058-3
Jagat R. Kanwar, Xueying Sun, Vasu Punj, Bhasker Sriramoju, Rajiv R. Mohan, Shu-Feng Zhou, Ashok Chauhan, Rupinder K. Kanwar, Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal. Nanomedicine: Nanotechnology, Biology and Medicine. ,vol. 8, pp. 399- 414 ,(2012) , 10.1016/J.NANO.2011.08.006
Anna Valeria Vergoni, Giovanni Tosi, Raffaella Tacchi, Maria Angela Vandelli, Alfio Bertolini, Luca Costantino, Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution. Nanomedicine: Nanotechnology, Biology and Medicine. ,vol. 5, pp. 369- 377 ,(2009) , 10.1016/J.NANO.2009.02.005
Mohammad R. Siahi-Shadbad, Kofi Asare-Addo, Kakali Azizian, Davoud Hassanzadeh, Ali Nokhodchi, Release behaviour of propranolol HCl from hydrophilic matrix tablets containing psyllium powder in combination with hydrophilic polymers Aaps Pharmscitech. ,vol. 12, pp. 1176- 1182 ,(2011) , 10.1208/S12249-011-9687-X
Ivona Brasnjevic, Harry WM Steinbusch, Christoph Schmitz, Pilar Martinez-Martinez, European NanoBioPharmaceutics Research Initiative, Delivery of peptide and protein drugs over the blood-brain barrier. Progress in Neurobiology. ,vol. 87, pp. 212- 251 ,(2009) , 10.1016/J.PNEUROBIO.2008.12.002
Thirumala Govender, Snjezana Stolnik, Martin C Garnett, Lisbeth Illum, Stanley S Davis, PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. Journal of Controlled Release. ,vol. 57, pp. 171- 185 ,(1999) , 10.1016/S0168-3659(98)00116-3
Reinhard Gabathuler, Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiology of Disease. ,vol. 37, pp. 48- 57 ,(2010) , 10.1016/J.NBD.2009.07.028
Nathan Schmidt, Abhijit Mishra, Ghee Hwee Lai, Gerard C.L. Wong, Arginine‐rich cell‐penetrating peptides FEBS Letters. ,vol. 584, pp. 1806- 1813 ,(2010) , 10.1016/J.FEBSLET.2009.11.046