Advanced Parkinson's disease: Clinical characteristics and treatment. Part II
作者： J. Kulisevsky , M.R. Luquin , J.M. Arbelo , J.A. Burguera , F. Carrillo
DOI: 10.1016/J.NRLENG.2013.05.002
关键词:
摘要: Abstract Introduction A large percentage of patients with Parkinson's disease (PD) develop motor fluctuations, dyskinesias, and severe non-motor symptoms (NMS) within 3 to 5 years starting dopaminergic therapy, these complications are refractory treatment. Several authors refer this stage the as advanced PD. Objective To define clinical manifestations PD risk factors for reaching disease. Development This consensus document has been prepared by using an exhaustive literature search discussion contents expert group on movement disorders Sociedad Espanola de Neurologia (Spanish Neurology Society), coordinated two (JK MRL). Conclusions Severe fluctuations axial resistant levodopa, cognitive decline main signs in phenotype
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