Mitochondrial Dynamics and Heart Failure.

摘要: Mitochondrial dynamics, fission and fusion, were first identified in yeast with investigation heart cells beginning only the last 5 to 7 years. In ensuing time, it has become evident that these processes are not required for healthy mitochondria, but also, derangement of contributes disease. The fusion proteins have a number functions beyond mitochondrial dynamics. Many related their membrane activities, such as apoptosis. However, other involve areas OPA1's role maintaining cristae structure preventing cytochrome c leak, its essential (at least 10 kDa fragment OPA1) mtDNA replication. disease, changes expression important can detrimental effects on cellular function.