Inhibition of peroxidase and catalase activities and modulation of hydrogen peroxide level by inositol phosphoglycan-like compounds.

摘要: Inositol phosphoglycan-like compounds are produced by the hydrolysis of membrane bound glycosyl phosphoinositides. Besides being short term mediators insulin action, they inhibit peroxidases and catalase, increasing concentration cellular hydrogen peroxide. Although high concentrations peroxide toxic, moderate increases its basal level signals for different metabolic pathways. The inhibitor, localized in cytosol cell, acts on catalase same tissue (homologous action) other tissues or organisms (heterologous action). inositol compound inhibits with prosthetic groups, i.e. containing iron such as: thyroid peroxidase, lactoperoxidase, horseradish soy bean peroxidase; selenium as glutathione peroxidase 2-cys peroxiredoxin no group. peroxidases, another heme enzyme. inhibition kinetics demonstrates a noncompetitive effect. site action is not group, given that inhibitor does produce any effect peak Soret region presence absence In conclusion, general involved modulation pathways signal transducer.