Milk diets influence doxorubicin-induced intestinal toxicity in piglets

摘要: Chemotherapy-induced gastrointestinal (GI) toxicity is a common adverse effect of cancer treatment. We used preweaned piglets as models to test our hypothesis that the immunomodulatory and GI trophic effects bovine colostrum would reduce severity complications associated with doxorubicin (DOX) Five-day-old pigs were administered DOX (1 × 100 mg/m(2)) or an equivalent volume saline (SAL) either fed formula (DOX-Form, n = 9, SAL-Form, 7) (DOX-Colos, SAL-Colos, 7). Pigs euthanized 5 days after initiation chemotherapy assess markers small intestinal function inflammation. All DOX-treated animals developed diarrhea, growth deficits, leukopenia. However, intestines DOX-Colos had lower permeability, longer villi higher activities brush border enzymes, tissue IL-8 levels compared DOX-Form (all P < 0.05). pigs, but not significantly plasma C-reactive protein, SAL-Form. Plasma citrulline was affected by treatment diet. Thus single dose induces in may lead systemic inflammatory response. The type enteral nutrition more pronounced when colostrum. results indicate be beneficial supplementary diet for children subjected subsequent toxicity.