Malignant neoplasms in cyclosporin A-induced autoimmunity (CyA-AI)

摘要: Lethally X-irradiated LEW rats reconstituted with syngeneic bone marrow and given low-dose Cyclosporine A (CyA) for 5 weeks develop, after withdrawal of CyA, symptoms disease resembling graft-vs.-host (GVHD) as seen allogeneic bone-marrow transplantation. Symptoms may include acute dermatitis chronic scleroderma. Since anti-class II MHC cytotoxic lymphocytes are generated in this model, it has been proposed an anti-tumor regimen humans. We now report that treated according to protocol may, cessation CyA administration, paradoxically develop malignant neoplasms. Of 48 experimental animals, 31 developed rapidly progressive subcutaneous and/or intracutaneous tumors commencing at 6 weeks, 13 months CyA. Tumors were mesenchymal origin, usually high-grade sarcoma, adenocarcinoma or both epithelial tumors. Such tumor incidence exceeded the growth controls, subjected thymectomy prior X-irradiation administration. by itself induced no Our results show total body is required development but presence CyA-induced autoimmune increases significantly.