Polymorphisms in androgen signaling pathway predisposing to prostate cancer.

摘要: Prostate cancer is the most frequent male malignancy diagnosed in western countries and androgens are known to mediate key physiological processes prostate tissue. Since endogenous have long been considered be risk factors for cancer, genes involved androgen biosynthesis metabolism extensively studied. In this review, association of pathway genes, their polymorphic sites different ethnic backgrounds addressed together with use predict susceptibility clinical outcomes patients. The effect polymorphisms seems vary patients, populations backgrounds. To date it evident that between gene complex many results characterized by irreproducibility, which can attributed a variety biological, statistical technical reasons. future, increasing knowledge, developing technologies new genomic biomarkers likely becomes possible better estimate distinguish indolent disease from aggressive based on molecular profiling, analysis gene–gene gene–environment interactions.