Understanding Neuropathic Pain

摘要: Neuropathic pain is defined as a chronic condition that occurs or persists after primary lesion dysfunction of the peripheral central nervous system. Traumatic injury nerves also increases excitability nociceptors in and around nerve trunks involves components released from terminals (neurogenic inflammation) immunological vascular cells resident within recruited into affected area. Action potentials generated injured fibers release excitatory neurotransmitters at their synaptic such L-glutamate substance P trigger cellular events system extend over different time frames. Short-term alterations neuronal excitability, reflected for example rapid changes discharge activity, are sensitive to conventional analgesics, do not commonly involve activity-dependent gene expression. Novel compounds new regimens drug treatment influence long-term transducing suppressive systems (pain matrix) emerging.