Experimental acute pancreatitis: In vitro models

摘要: Acute pancreatitis is an extremely painful and lifethreatening inflammatory disease of the exocrine pancreas (57, 100). A sobering point for both clinicians researchers that treatment acute remains largely supportive. Further, there a lack therapies target primary mechanisms underlying initiation or propagation disease. Thus reliable, relevant, and, importantly, convenient experimental animal models resemble human are crucial to developing understanding pathobiology (34, 35, 104, 105, 108, 110). In this chapter, we will review current in vitro (i.e. ex vivo) serve as surrogates pancreatitis. We specifically discuss: (1) standard process preparing pancreatic acinar cells tissue components; (2) assays assessing injury precursors; (3) array non-alcoholic alcoholic