Genome-Wide Analysis of Translational Control

摘要: The importance of translational deregulation specific transcripts in cancer has emerged during the last decade. For a more complete understanding control cancer, genome-wide studies are essential. In this chapter we describe methods that make such analysis possible and identify several key aspects experimental design data which essential for an informative study. We further review have used approaches to gain insights models with particular focus on downstream eIF4E. Finally introduce “integrative translatomics” as means link patterns molecular mechanisms originating from RNA sequences. This information may prove be comprehensive how pathological mediates acquisition malignant phenotype.