Long-term survival and recurrence-free interval in combined surgical, radio- and chemotherapy of malignant brain gliomas.

摘要: A prospective randomized study has been conducted since 1978 to judge the value of combined radio- and chemotherapy (CCNU) in postoperative treatment grade III IV supratentorial gliomas. Inoperable or recurrent tumors were excluded from these series, but evaluated addition. Increase median survival time (18 months) for entire series (62.2% glioblastomas) was only small compared other mentioned literature, there a significant prolongation recurrence-free interval (16.5 total onset symptoms 46.4% cases living more than 18 months. If 'useful recovery' is major goal present cancer, fraction long-term survivors may be important statistical parameters time. To improve 'quality life' number patients (so-called survivors) length intervals should therapeutic goal, even if overall remains essentially unaffected. We conclude that therapy, including chemotherapy, following surgical resection most malignant glioma.