Multidrug Resistence and Breast Cancer

摘要: Millions of new cancer patients are diagnosed each year and over half these die from this disease. As the second leading cause deaths, breast is estimated to be in one million people worldwide more than 400,000 deaths [1]. Chemotherapy part a successful treatment many cases; however, development multidrug resistance (MDR) it becomes major obstacle so as few treated benefit chemotherapy. MDR term used describe phenomenon characterized by ability drug resistant tumors exhibit simultaneous number structurally functionally unrelated chemotherapeutic agents [2]. The cytotoxic drugs that most frequently associated with hydrophobic, amphipathic natural products, such taxanes (paclitaxel docetaxel), vinca alkaloids (vinorelbine, vincristine, vinblastine), anthracyclines (doxorubicin, daunorubicin, epirubicin), epipodophyllotoxins (etoposide teniposide), antimetabolites (methorexate, fluorouracil, cytosar, 5-azacytosine, 6-mercaptopurine, gemcitabine) topotecan, dactinomycin, mitomycin C on[3]. At present, mechanisms have been found responsible for it, including overexpression members adenosine triphosphate (ATP)-binding cassette (ABC) membrane transporter family, changes apoptosis-related genes, alteration DNArepair gene, stem cells on. And up date, methods were adopted overcome MDR, example natrual drugs, chemical genetic therapy. Herein, we will introduce therapy briefly.