Interaction of Developmental Venous Anomalies with Resting-State Functional MRI Measures.

摘要: BACKGROUND AND PURPOSE: Functional MR imaging of the brain, used for both clinical and neuroscientific applications, relies on measuring fluctuations in blood oxygenation. Such measurements are susceptible to noise vascular origin. The purpose this study was assess whether developmental venous anomalies, which frequently observed normal variants, can bias fMRI measures by appearing as true neural signal. MATERIALS METHODS: Large anomalies (1 each 14 participants) were identified from a large neuroimaging cohort (n = 814). Resting-state data decomposed using independent component analysis, data-driven technique that creates distinct maps representing aspects either structured or activity. We searched all components exhibited spatial distribution their signals following topography anomalies. RESULTS: Of identified, 10 clearly present 17 total. While 9 (52.9%) these dominated contributions 2 (11.8%) motion artifacts, showed partial signal 5 (29.4%) unambiguously typical patterns. CONCLUSIONS: Developmental strongly resemble measured fMRI. They thus potential source analyses, especially when cortex. This could impede interpretation local activity patients, such presurgical mapping. In scientific studies with samples, anomaly confounds be mainly addressed analysis–based denoising.