The new concepts on overcoming drug resistance in lung cancer
作者： Xifeng Dong , Cuiping Xu , Ping Lei , Weisan Zhang
DOI: 10.2147/DDDT.S60672
关键词:
摘要: Lung cancer is one of the most deadly diseases worldwide. The current first-line therapies include chemotherapy using epidermal growth factor receptor tyrosine kinase inhibitors and radiotherapies. With progress in identifying new molecular targets, acquired drug resistance stands as an obstacle for good prognosis. About half patients receiving receptor-tyrosine inhibitor treatments develop resistance. Although extensive studies have been applied to elucidate underlying mechanisms, evidence far from enough establish a well-defined picture correct In review, we will discuss four different currently developed strategies that potential overcome lung facilitate prolonged anticancer effects therapies.
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