摘要: The relationship of the parathyroid gland to calcium metabolism had been known for many years, but it was not realized until 1926 that widespread decalcification skeleton can be produced by a functioning tumor. This discovery provided wealth new information relative abnormal bone and also furnished clue successful treatment hyperparathyroidism surgical extirpation In certain cases, however, clinical picture entirely typical hyperparathyroidism. 1 bony lesions developed in childhood were spotty or disseminated rather than generalized 2 sometimes predominantly unilateral. 3 Extraskeletal abnormalities, such as large areas cutaneous pigmentation, noted, females precocious puberty an outstanding feature. 4 Three seemingly dissociated manifestations, namely, fibrosis bone, pigmentation among females, completed syndrome which Albright his co-workers 5 described