High-Throughput Screening for Inhibitors of Wall Teichoic Acid Biosynthesis in Staphylococcus aureus.
作者： Omar M. El-Halfawy , Eric D. Brown
DOI: 10.1007/978-1-4939-9154-9_23
关键词:
摘要: The world is heading toward a dangerous post-antibiotic era where antibiotics fail to treat infections. Staphylococcus aureus the leading cause of healthcare-associated infections worldwide, and an ever-increasing percentage them are methicillin-resistant (MRSA). New strategies urgently needed combat this pathogen. Wall teichoic acids (WTA) in S. polyribitol phosphate polymers that play important roles virulence resistance β-lactam antibiotics. Here, we describe high-throughput whole-cell screening platform for inhibitors targeting WTA biosynthesis. This takes advantage unique dispensability patterns genes encoding We further follow-up dose-response assays identify among primary bioactives. offer exciting opportunity development novel antibacterial leads mechanism fight against drug-resistant staphylococcal
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