Symptom dimensions as alternative phenotypes to address genetic heterogeneity in schizophrenia and bipolar disorder.

摘要: This study introduces a novel way to use the lifetime ratings of symptoms psychosis, mania and depression in genetic linkage analysis schizophrenia (SZ) bipolar disorder (BP). It suggests using latent class model developed for family data define more homogeneous symptom subtypes that are influenced by smaller number genes will thus be easily detectable. In two-step approach, we proposed: (i) form clusters subjects based on dimensions (ii) information from these analysis. framework was applied unique SZ BP sample composed 1278 48 large kindreds Eastern Quebec population. The results suggest our strategy has power increase signals previously obtained diagnosis as phenotype allows better characterization signals. is case signal, which formerly chromosome 13q enhanced dimension mania. also methods may detect new not uncovered alone, chromosomes 2q (delusion), 15q (bizarre behavior), 7p (anhedonia) 9q (delusion). region, coincide with detected other studies. Our support view dissecting phenotypic heterogeneity modeling provide insights into genetics BP.