作者: Renato Vieira dos Santos , Linaena Méricy da Silva
DOI: 10.1371/JOURNAL.PONE.0069131
关键词:
摘要: A controversy surrounds the frequency of cancer stem cells (CSCs) in solid tumors. Initial studies indicated that these had a ranging from 0.0001 to 0.1% total cells. Recent have shown this does not always seem be case. Some [Formula: see text]. In paper we propose stochastic model is able capture potential variability CSCs among various type Considerations regarding heterogeneity tumor and its consequences are included. Possible effects on conventional treatments clinical practice also described. The results suggest traditional attempts combat with rapid cycling can very stimulating for cell populations.