A Possible Explanation for the Variable Frequencies of Cancer Stem Cells in Tumors

作者: Renato Vieira dos Santos , Linaena Méricy da Silva

DOI: 10.1371/JOURNAL.PONE.0069131

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摘要: A controversy surrounds the frequency of cancer stem cells (CSCs) in solid tumors. Initial studies indicated that these had a ranging from 0.0001 to 0.1% total cells. Recent have shown this does not always seem be case. Some [Formula: see text]. In paper we propose stochastic model is able capture potential variability CSCs among various type Considerations regarding heterogeneity tumor and its consequences are included. Possible effects on conventional treatments clinical practice also described. The results suggest traditional attempts combat with rapid cycling can very stimulating for cell populations.

参考文章(75)
Anna Kane Laird, Dynamics of Tumour Growth British Journal of Cancer. ,vol. 18, pp. 490- ,(1964)
Richard Kavinoky, John B. Thoo, The Number of Real Roots of a Cubic Equation. The AMATYC Review. ,vol. 29, pp. 2- 8 ,(2008)
Martin M. Eisen, Carole A. Eisen, Probability and its applications Quantum Publishers. ,(1975)
Robert L. Devaney, Stephen Smale, Morris W. Hirsch, Differential Equations, Dynamical Systems, and an Introduction to Chaos ,(2003)
Francesco Laio, Paolo D'Odorico, Luca Ridolfi, Noise-Induced Phenomena in the Environmental Sciences ,(2011)
Peter E Kloeden, Eckhard Platen, Matthias Gelbrich, Werner Romisch, Numerical Solution of Stochastic Differential Equations ,(1992)
Samuel Karlin, Howard E Taylor, A second course in stochastic processes ,(1981)